• Computational Biophysics at Illinois Tech

    We use physics and computation to uncover how molecules give rise to life, from the structure of DNA to the function of cells.

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  • Computational Biophysics at Illinois Tech

    We use and develop theoretical chemistry and biophysical techniques to understand the physical basis of biological phenomena.

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About Our Group

The Wereszczynski Lab uses advanced computer simulations and physical models to reveal how proteins, DNA, and other molecules work together to create life. We explore how the motions and interactions of these molecules control gene expression, shape chromatin structure, and drive essential cellular processes. By developing new simulation techniques and applying them to challenging problems, we uncover the physical principles behind some of biology’s most fundamental questions.

Our team works at the intersection of physics, chemistry, and biology, bringing together ideas and tools from across the sciences. We are based in the Physics Department at Illinois Tech, where we collaborate with experimentalists and theorists to push the boundaries of molecular biophysics.

This work is currently funded by a Maximizing Investigators’ Research Award (MIRA) from the NIH. Previous support includes grants from NIH and NSF, including an NSF CAREER Award.

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Selected Publications

“Mechanistic Basis for the Opposing Effects of H2A and H2B Ubiquitination on Nucleosome Stability and Dynamics”

L. Baweja and J. Wereszczynski

“Modeling Allosteric Mechanisms of Eukaryotic Type II Topoisomerases”

S. Evoli, N. L. Kariyawasam, K. C. Nitiss, J. L. Nitiss, J. Wereszczynski

“Conformational and Thermodynamic Differences Underlying Wild-type and Mutant YEATS Domain Specificity for Epigenetic Marks”

L. Baweja and J. Wereszczynski

“Directed inter-domain motions enable the IsdH Staphylococcus aureus receptor to rapidly extract heme from human hemoglobin”

J. Clayton, K. Ellis-Guardiola, B. Mahoney, J. Soule, R. T. Clubb, Jeff Wereszczynski