• Computational Biophysics at Illinois Tech

    We use and develop theoretical chemistry and biophysical techniques to understand the physical basis of biological phenomena.

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  • Computational Biophysics at Illinois Tech

    We use and develop theoretical chemistry and biophysical techniques to understand the physical basis of biological phenomena.

    Read More

About Our Group

The Wereszczynski Lab focuses on using and developing theoretical chemistry and biophysical techniques to discern the physical basis of biological phenomena. To do this, we perform intensive computer simulations that quantify the motions of proteins, DNA, and other biological molecules to determine how their functions are influenced by their dynamics, and how these properties are influenced by interactions with other organic and inorganic molecules that exist in the cell.

We are members of the IIT Physics Department, and the Center for Molecular Study of Condensed Soft Matter (uCoSM), which is part of the Pritzker Institute of Biomedical Science & Engineering at IIT. In addition, we are affiliated with the Biophysics Collaborative Access Team (BioCAT), an NIH funded X-ray facility located at Argonne National Laboratory.

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Selected Publications

“Modeling Allosteric Mechanisms of Eukaryotic Type II Topoisomerases”

S. Evoli, N. L. Kariyawasam, K. C. Nitiss, J. L. Nitiss, J. Wereszczynski

“Conformational and Thermodynamic Differences Underlying Wild-type and Mutant YEATS Domain Specificity for Epigenetic Marks”

L. Baweja and J. Wereszczynski

“Directed inter-domain motions enable the IsdH Staphylococcus aureus receptor to rapidly extract heme from human hemoglobin”

J. Clayton, K. Ellis-Guardiola, B. Mahoney, J. Soule, R. T. Clubb, Jeff Wereszczynski

“CENP-N promotes the compaction of centromeric chromatin”

K. Zhou, M. Gebala, D. C. Woods, K. Sundararajan, G. Edwards, D. Krzizike, J. Wereszczynski, A. F. Straight, K. Luger